Most people who have contact with a dog or cat do not become sick. Download fulltext pdf capnocytophaga gingivalis aminopeptidase. Capnocytophaga is a genus of gramnegative bacteria. Capnocytophaga synonyms, capnocytophaga pronunciation, capnocytophaga translation, english dictionary definition of capnocytophaga. Capnocytophaga is the name of a group of gramnegative bacteria that live in the mouth of some animals and humans. In vitro susceptibilities of capnocytophaga isolates to.
Pyogenic arthritis caused by capnocytophaga gingivalis in an. Capnocytophaga granulosa and capnocytophaga haemolytica. Capnocytophaga ochracea, capnocytophaga sputigena and capnocytophaga gingivalis. Capnocytophaga canimorsus is a fastidious, slowgrowing, gramnegative rod of the genus capnocytophaga. To view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Genetic tools for studying capnocytophaga canimorsus.
Capnocytophaga species infectious disease and antimicrobial. They were the earliest bacteria to be isolated and named from the human subgingival plaque. Emended description of capnocytophaga gingivalis free. Golenbock,2 and yoshitaka hara1 department of periodontology, nagasaki university school of dentistry, 171 sakamoto, nagasaki 8528588, japan,1. Capnocytophaga canimorsus, a commensal bacterium from canine oral flora, has been isolated throughout the world from severe human infections caused by dog bites. Capnocytophaga canimorsus is the species most commonly involved in zoonotic. Hence, most studies to date have reported these isolates as. Bacteria of the genus capnocytophaga are recently recognised pathogens which may cause oral disease and subsequent septicaemia in the immunocompromised host. A genus of bacteria comprising fusiform, fermentative, gramnegative rods which require carbon dioxide for growth and show gliding motility explanation of capnocytophaga canimorsus.
Capnocytophaga ochracer, capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga granulose, and capnocytophaga heamolytica. Lipopolysaccharides from periodontopathic bacteria porphyromonas gingivalis and capnocytophaga ochracea are an tagonists for human tolllike receptor 4. Capnocytophaga species are facultative anaerobic, capnophilic, fusiform, gramnegative bacilli exhibiting gliding motility. Microorganism capnocytophaga gingivalis 2010 infection and. Completion of the reaction was determined spectrophotometrically from the. Clinical isolates of capnocytophaga spp are classified into two broad groups. Here, we show that tn 4351, derived from bacteroides fragilis, could be. See the preventing dog bites page for information on how to prevent dog bites and what to do if you are bitten, regardless of your health status. The susceptibilities of the 43 capnocytophaga strains to three betalactam antibiotics and three betalactamase inhibitors, alone or in combination, expressed as the range of mics and the mics at which 50% mic 50 and 90% mic 90 of the strains are inhibited, are shown in table table1. Detection, identification, comparison capnocytophaga, bacteroides. The genus capnocytophaga includes three bacterial species. This pathogen has a unique shape and outer layer, and can cause severe illness if not treated quickly and.
Lipopolysaccharides from periodontopathic bacteria. The frequency with which these bacteria have been isolated in large patient series ranges from 0. Porphyromonas gingivalis and capnocytophaga ochracea are antagonists for human tolllike receptor 4 atsutoshi yoshimura, 1 takashi kaneko, yoshifumi kato, douglas t. Transmission may occur through bites, licks, or even close proximity with animals.
Thisdesignation is aptfor all ofthese strains, andweconcurwithsocranskyetal. Article information, pdf download for microbial pathogenicity. Capnocytophaga canimorsus article about capnocytophaga. Capnocytophaga ochracea is an aerotolerant anaerobe that requires either an anaerobic environment or 5% co2 concentration of the gaseous form or 20 mm hco3 in the hydrated form 7. What is capnocytophaga how common is capnocytophaga. The genus consists of seven species, namely capnocytophaga gingivalis, c. May 16, 2020 capnocytophaga canimorsus is a type of bacteria that exists in the mouths of healthy dogs and cats. Sixtyeight strains of capnophilic fusiform gramnegative rods from the human oral cavity were subjected to extensive physiologic characterization, tested for susceptibility to various antibiotics, and the molpercent guanine plus cytosine of each isolate determined. The word element capno in the bacteriums name refers to its ability to survive in high levels of carbon dioxide. Bacteremia caused by capnocytophaga species in patients with.
Assessment of five culture media for the growth and isolation of. Capnocytophaga are gramnegative, facultative anaerobic bacteria. Microbial pathogenicity blackpigmented bacteroides species. A potential virulence factor article pdf available in microbiology 141 pt 1212. Many works have also shown that oral pathogens are essential in the development of colorectal and pancreatic. Capnocytophaga gingivalis 2010 was monitored optically at 540 nm. This bacteria can cause sepsis in people after an animal bite. Capnocytophaga ochracea, capnocytophaga sputigena, and capnocytophaga gingivalis.
Capnocytophaga spp consists of facultative anaerobic gram. Atsutoshi yoshimura department of periodontology, nagasaki university school of dentistry, 171 sakamoto, nagasaki 8528588, japan. Capnocytophaga canimorsus formerly cdc group df2 and capnocytophaga cynodegmi cdc group df2 like were proposed as two new species 1. Antimicrobial treatment of capnocytophaga infections. Infections are more often linked to dog bites or dog contact. Capnocytophaga gingivalis definition of capnocytophaga. In addition, they are opportunistic pathogens associated with periodontal diseases and animal bites, causing systemic infection in both immunocompetent and immunocompromised hosts 2, 3. Rarely, capnocytophaga germs can spread to people through bites, scratches, or close contact from a dog or cat and may cause illness, including sepsis. Get a printable copy pdf file of the complete article 4. Pdf capnocytophaga species belong to the oral microbiota but are not a common cause of infection in febrile neutropenia. Capnocytophaga sputigena bacteremia in a patient with.
Pdf identification of capnocytophaga species from oral cavity of. It is a commensal bacterium in the normal gingival flora of canine and feline species, but can cause illness in humans. People with a weakened immune systems who have difficulty fighting off infections for example, people with cancer or those. The data suggest that the glucose is catabolized by a fully aerobic route.
A gramnegative, microaerophilic, co2requiring gliding bacillus, which is found in normal oral flora and an opportunistic pathogen. Capnocytophaga canimorsus is a bacterial cause of fulminant sepsis among individuals who have been bitten by a dog. Human oral capnocytophaga species have been only rarely described as a cause of sepsis in patients following stem cell or marrow transplantation, and pneumonia has not been reported in this setting. Aclq0000 capnocytophaga gingivalis atcc 33624, whole genome shotgun sequencing project. Effects of glucose concentration on growth and hydrolytic enzyme production article pdf available in microbiology 142 pt 88. Antibiotic content of selective culture media for isolation. Ninetyseven strains of capnocytophaga isolated from the oral cavity and the type strains of c. We present two cases of infection caused by capnocytophaga ochracea. Find out information about capnocytophaga canimorsus. Emended description of capnocytophaga gingivalis microbiology. Pdf capnocytophaga sputigena bacteremia in a neutropenic host.
Due to the low level of evolutionary relationship to proteobacteria, genetic methods suitable for the genus capnocytophaga needed to be established. Theirstudiessuggest that this genus includes at least three distinct biogroups. Keratocyst capnocytophaga superinfection rua gonzalvez. Capnocytophaga definition of capnocytophaga by the free. Normally found in the oropharyngeal tract of mammals, they are involved in the pathogenesis of some animal bite wounds and periodontal diseases. Although the genus is known to contain five human oral isolates, accurate identification to species level of these organisms recovered from subgingival plaque has been hampered by the lack of a reliable method.
The first group is made up of the two species located in animal oral cavities and the second one is formed by the seven human species capnocytophaga ochracea, capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga granulosa, capnocytophaga. Capnocytophaga species have been implicated as putative periodontal pathogens. The subacute presentation of the monoarthritis with this organism of low virulence led. Many kinds of bacteria germs called capnocytophaga live in the mouths of dogs and cats. Aug 15, 2001 capnocytophaga species are a rare cause of bacteremia in patients with neutropenia and cancer.
In chemostat culture, the microaerophilic, co 2 requiring, gingivalplaqueassociated bacterium capnocytophaga gingivalis responded to the addition of glucose 16 g i1 by doubling its growth rate and increasing its biomass yield fivefold. Pneumonia and sepsis due to fluoroquinoloneresistant. Ab032576 capnocytophaga gingivalis gyrb gene for dna gyrase b subunit, partial cds. Capnocytophaga definition of capnocytophaga by medical. Microscopy of capnocytophaga sputigena, capnocytophaga. The characteristics of the isolates were compared with 10 fresh and 2 stock isolates of fusobacterium nucleatum. Get a printable copy pdf file of the complete article 796k, or click on a page. The genus initially included three species on the basis of morphological, physiological and dna data. It is rod shaped and is able to grow rapidly under the right conditions. Although occasionally found in soil and water, the predominant natural habitat of capnocytophaga species is the human oropharynx.